Structural basis of α-scorpion toxin action on Nav channels
نویسندگان
چکیده
منابع مشابه
The Paradox of Scorpion Toxin Interactions with Portable Nav Receptors
Scorpion venom is rich in proteinaceous toxins that affect excitability by impeding ion channel gating. Channel blockers interact with the external region of the pore and obstruct ion conductance, whereas channel modifiers interact with the voltage sensor module hindering the activation or inactivation processes [1-3]. Scorpion toxin modifiers of voltage-gated sodium channels (Navs) are divided...
متن کاملα-Scorpion Toxin Impairs a Conformational Change that Leads to Fast Inactivation of Muscle Sodium Channels
Alpha-scorpion toxins bind in a voltage-dependent way to site 3 of the sodium channels, which is partially formed by the loop connecting S3 and S4 segments of domain IV, slowing down fast inactivation. We have used Ts3, an alpha-scorpion toxin from the Brazilian scorpion Tityus serrulatus, to analyze the effects of this family of toxins on the muscle sodium channels expressed in Xenopus oocytes...
متن کاملScorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes
Scorpion β toxins, peptides of ∼70 residues, specifically target voltage-gated sodium (Na(V)) channels to cause use-dependent subthreshold channel openings via a voltage-sensor trapping mechanism. This excitatory action is often overlaid by a not yet understood depressant mode in which Na(V) channel activity is inhibited. Here, we analyzed these two modes of gating modification by β-toxin Tz1 f...
متن کاملInteraction of Scorpion α-Toxins with Cardiac Sodium Channels
The effects of the scorpion alpha-toxins Lqh II, Lqh III, and LqhalphaIT on human cardiac sodium channels (hH1), which were expressed in human embryonic kidney (HEK) 293 cells, were investigated. The toxins removed fast inactivation with EC(50) values of <2.5 nM (Lqh III), 12 nM (Lqh II), and 33 nM (LqhalphaIT). Association and dissociation rates of Lqh III were much slower than those of Lqh II...
متن کاملScorpion toxin peptide action at the ion channel subunit level
This review categorizes functionally validated actions of defined scorpion toxin (SCTX) neuropeptides across ion channel subclasses, highlighting key trends in this rapidly evolving field. Scorpion envenomation is a common event in many tropical and subtropical countries, with neuropharmacological actions, particularly autonomic nervous system modulation, causing significant mortality. The prim...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2019
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aav8573